Ganduri Sailesh

Multiparticulate Drug Delivery System for Telmisartan: Pellets for Enhancing the Dissolution Ganduri Sailesh

Multiparticulates or pellets are more popular as sustained released dosage forms. These multiparticulates offer flexibility in dosage form design by filling them into capsule, compression into a tablet either conventional or fast dissolving or into sachets that can be administered along with food. They are also helpful in minimizing the effect of food on absorption as they flow freely in the gastro-intestinal tract irrespective of presence or absence of food and the opening or closing nature of pyloric sphincter. This book therefore provides an approach of pellets for enhancing dissolution rate of Telmisartan using different carriers like PVP, PEG 4000, PEG 6000, Mannitol, Sodium Lauryl Sulphate, Magnesium Oxide and Sodium bicarbonate along with various manufacturing methods, advantages, various technologies that employ pellets. Factorial design was used for optimizing the concentration of carrier and size of the pellets. Use of Magnesium oxide and Sodium bicarbonate satisfied the dissolution requirements. Size of non-pareil seeds and carrier ratio were optimized using a 2x2 factorial design.