Da'san M. M. Jaradat

Multivalency & Glycopeptides: Novel Analogues of Glycopeptides by Staudinger Reactions (Experimental Overview) Da'san M. M. Jaradat

Bioorganic chemistry is interdisciplinary branch of life science that employs chemical methods to understand and solve biological problems. Multivalency is the capability of a molecule (entity) to bind and interact with another molecule (entity) through multiple simultaneous noncovalent interactions. Glycoconjugates, indeed glycopeptides, are desirable targets for synthesis and for the investigation of the biological properties. In this book, the utilization of Staudinger-type reactions to access multivalency and to synthesize natural and unnatural glycoconjugates is presented. This book provides detailed theoretical and experimental background on the implementation of Traceless Staudinger Ligation (TSL) and Staudinger Phosphite Reaction (SPR) to achieve multivalency and analogues of glycopeptides. For instance, the synthesis of mimetics of phospho- glycopeptides found in the parasite Leishmania Mexicana is presented.