Mariya Yakovleva

Perifericheskaya Neyropatiya Pri Paraproteinemicheskikh Gemoblastozakh: Klinicheskie Osobennosti I Varianty Korrektsii Mariya Yakovleva Russian edition

Rabota yavlyaetsya pervym otechestvennym issledovaniem, posvyashchennym tselenapravlennomu i vsestoronnemu izucheniyu klinicheskikh osobennostey perifericheskoy neyropatii u patsientov s paraproteinemicheskimi gemoblastozami. V rabote rassmotren ryad voprosov patogeneza paraprotein-assotsiirovannykh i lekarstvennykh, v tom chisle bortezomib-indutsirovannykh neyropatiy, opredeleny faktory riska, pokazateli dozozavisimosti i kriterii stadirovaniya. Predstavleny varianty optimizatsii i predlozheny k prakticheskomu primeneniyu skhemy obsledovaniya, profilaktiki lecheniya i korrektsii perifericheskoy neyropatii pri gemoblastozakh. Aktual'nost' rassmatrivaemoy temy obuslovlena dostatochno vysokoy vstrechaemost'yu dannoy patologii i neobkhodimost'yu izucheniya voprosov patogeneza, profilaktiki, doklinicheskoy diagnostiki, stadirovaniya, prognozirovaniya techeniya i tempov vosstanovleniya narushennykh funktsiy, razrabotki taktiki vedeniya i effektivnogo lecheniya, a takzhe profilaktiki razlichnykh variantov polineyropatiy u patsientov s paraproteinemicheskimi gemoblastozami.