Anupama A. Parate

The Synthetic Variants of Angiotensin II Receptor Antagonists: an Update on Aiirbs Anupama A. Parate

Angiotensin II receptor antagonists also known as angiotensin receptor blockers (ARBs), AT1-receptor antagonists or sartans, are a group of pharmaceuticals that regulate and modulate the renin-angiotensin-aldosterone system. Their main uses are in the treatment of hypertension (high blood pressure), diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure. The book covers an account of the synthesis of heterocyclic, aromatic, cyclic and acyclic analogues of compounds synthesised as angiotensin II receptor antagonists. It also comprises details of molecular modelling studies of angiotensin II receptor antagonists as antihypertensive agents.