Arumugam Geetha

Functional Aspects of Platelets in Liver Cirrhosis: Influence of Nitric Oxide, Cgmp and Cytosolic Calcium - an in Vitro Study Arumugam Geetha

Liver diseases are often associated with abnormal bleeding and show multiple, complicated hemostatic abnormalities primarily due to clotting factor deficiency and secondarily due to thrombocytopenia and platelet dysfunction. Though the prevalence of platelet dysfunction in cirrhosis is reported, the data regarding the specific defect is lacking. The strategy is to develop an effective drug treatment that can focus on the exact platelet activation defect to reduce the bleeding complication in cirrhosis patients. This book deals with the influence of cytosolic calcium, cGMP, nitric oxide and nitric oxide synthase on platelet functions such as adhesion, aggregation and secretion in liver cirrhosis patients and the results might throw light on the future insights of platelet research towards bleeding complication in liver cirrhosis.