Mechanisms of Altered Hepatotoxicity in Nonalcoholic Fatty Liver: Mechanisms of Altered Hepatotoxicity in Hepatic Steatosis and Nonalcoholic Steatohepatitis - Shashikiran Donthamsetty - Libros - LAP Lambert Academic Publishing - 9783838309712 - 15 de septiembre de 2009
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Mechanisms of Altered Hepatotoxicity in Nonalcoholic Fatty Liver: Mechanisms of Altered Hepatotoxicity in Hepatic Steatosis and Nonalcoholic Steatohepatitis

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The objectives of this research were to investigate 1) if hepatic steatosis and nonalcoholic steatohepatitis (NASH) independently sensitize the liver to hepatotoxicity and 2) the mechanisms behind the increased sensitivity. Our study suggests that fatty hepatocytes fail to undergo compensatory cell division rendering the liver susceptible to progressive expansion of liver injury. In conclusion, impaired tissue repair response sensitizes the steatotic/steatohepatitic livers to hepatotoxicity.

Medios de comunicación Libros     Paperback Book   (Libro con tapa blanda y lomo encolado)
Publicado 15 de septiembre de 2009
ISBN13 9783838309712
Editores LAP Lambert Academic Publishing
Páginas 136
Dimensiones 225 × 8 × 150 mm   ·   221 g
Lengua Alemán