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The Role of Cytokines on Synaptic Plasticity in the Dentate Gyrus Derval Cumiskey
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The Role of Cytokines on Synaptic Plasticity in the Dentate Gyrus
Derval Cumiskey
Pro-inflammatory cytokines have been implicated in a wide range of central nervous system (CNS) disorders, including trauma, ischemia, multiple sclerosis and Alzheimer?s disease. Tumour necrosis factor-? (TNF-?) and interleukin-18 (IL-18), both pro-inflammatory cytokines, have previously been shown to attenuate long-term potentiation (LTP), a proposed model for learning and memory. This study investigated the mechanisms underlying the TNF-? and IL-18 mediated inhibition of LTP. Initial experiments consolidate evidence on inducing LTP in the dentate gyrus of the hippocampus. Subsequent experiments consolidate evidence that TNF-? and IL-18 can impair LTP in the dentate gyrus.
| Medios de comunicación | Libros Paperback Book (Libro con tapa blanda y lomo encolado) |
| Publicado | 8 de marzo de 2011 |
| ISBN13 | 9783844319941 |
| Editores | LAP LAMBERT Academic Publishing |
| Páginas | 260 |
| Dimensiones | 150 × 15 × 226 mm · 405 g |
| Lengua | Alemán |