Sergey Grigor'evich Pak

Autoimmunnye Proyavleniya U Bol'nykh Virusnymi Gepatitami: Monografiya Sergey Grigor'evich Pak Russian edition

Vyyavlennoe nalichie autoimmunnykh proyavleniy u bol'nykh virusnymi gepatitami na rannikh etapakh zabolevaniya pozvolyaet rekomendovat' issledovanie syvorotki krovi bol'nykh OVG na nalichie markerov autoimmunnykh narusheniy (neorganospetsificheskie autoantitela, revmatoidnyy faktor, krioglobuliny) dlya resheniya voprosa o neobkhodimosti dal'neyshego nablyudeniya i prognozirovaniya techeniya zabolevaniya. Pri otsenke morfofunktsional'nogo sostoyaniya gepatobiobtatov u bol'nykh khronicheskimi virusnymi gepatitami V i S prognosticheskim kriteriem yavlyaetsya ne tol'ko gistologicheskaya aktivnost' i vyrazhennost' fibroza, no i subpopulyatsionnyy sostav leykotsitarnykh infil'tratov v parenkhime pecheni. V parenkhime pecheni etikh bol'nykh nami vpervye byl vyyavlen kompleks T-regulyatornykh kletok (CD4+CD25+), kotoryy vyzyvaet supressiyu kletochnogo immunnogo otveta pri eliminatsii virusa i povrezhdennykh tkaney i obespechivaet razvitie persistiruyushchey virusnoy infektsii s autoimmunnym komponentom.