Assefa Sergawie

Voltammetric Study of Dipyrone Using Glassy Carbon Electrode: Electrochemical Behavior of Dipyrone Assefa Sergawie

Dipyrone is a well known water soluble white crystalline powder, a non-opiate and non-steroidal anti-inflammatory analgesic drug (NSAID) which belongs to the group of pyrazolones and widely used as analgesic, antipyretic, and antispasmodic drug in many pharmaceutical dosage forms. This work was aimed to develop suitable voltammetric methods such as CV, SW, and DPV for dipyrone study using glassy carbon electrode and to study the electrochemical behavior of dipyrone in a buffer solution at different concentrations, pH, and scan rates. In cyclic voltammetry and square wave voltammetry techniques, dipyrone undergoes four consecutive irreversible oxidation reactions at different oxidation potentials. While using differential pulse voltammetry, dipyrone undergoes two consecutive irreversible oxidation reactions. The peak at 0.45 V shows consistent behavior in all the techniques used under different experimental conditions. The anodic peak current of dipyrone decreases as pH increases but at higher pH the first oxidation reaction takes place at lower potential. the effect of concentration and scan rate is the same for all techniques.