German Perlovich

Lekarstvennye Soedineniya Gruppy Fenamatov: Termodinamicheskie Kharakteristiki Kristallov I Rastvorov German Perlovich Russian edition

Razrabotka novogo lekarstvennogo soedineniya (LS) ? prodolzhitel'nyy, naukoemkiy i dorogostoyashchiy protsess. Polnye raskhody tol'ko na nauchnye issledovaniya v amerikanskikh farmatsevticheskikh kompaniyakh v kontse 1990-kh godov sostavlyali bolee chem 20 milliardov dollarov v god, i eta tsifra postoyanno uvelichivaetsya. V svyazi s etim razrabotka nauchnykh osnov polucheniya vodorastvorimykh lekarstvennykh soedineniy yavlyaetsya krayne aktual'noy zadachey. Odnim iz putey resheniya problemy mozhet sluzhit' strukturnaya modifikatsiya soedineniya «lidera», privodyashchaya k umen'sheniyu energii kristallicheskoy reshetki bez narusheniya ego farmakologicheskikh svoystv. Krome togo, LS dolzhny obladat' optimal'nym sochetaniem lipofil'nykh i gidrofil'nykh svoystv, pozvolyayushchikh pronikat' cherez razlichnye vidy membran dlya dostizheniya biologicheskikh retseptorov. Tsennuyu informatsiyu o prirode vzaimodeystviy LS s membranami mozhno poluchit' na osnove analiza sol'vatatsionnykh kharakteristik vzaimodeystviya molekul s rastvoritelyami, modeliruyushchimi razlichnoe biologicheskoe okruzhenie.