Harikesh Maurya

Buccal Film (Enalapril): a Most Promising Route for Drug Delivery: Development & Evaluation of Buccal Films of Enalapril Maleate in the Management of Hypertension Harikesh Maurya

Hypertension is one of the most common worldwide diseases afflicting humans. Over the past several decades, extensive research, widespread patient education, and a concerted effort on the part of health care professionals have led to decreased mortality and morbidity rates from the multiple organ damage arising from years of untreated hypertension. Approximately 50 million people in the United States are affected by hypertension. Substantial improvements have been made with regard to improving awareness and treatment of hypertension. However, approximately 30% of adults are still unaware of their hypertension; up to 40% of people with hypertension are not receiving treatment; and, of those treated, up to 67% do not have their blood pressure (BP) controlled to less than 140/90 mm Hg. The classification of BP (expressed in mm Hg) for adults aged 18 years or older is as follows: Normal - Systolic lower than 120, diastolic lower than 80 Prehypertension - Systolic 120-139, diastolic 80-90 Stage 1 - Systolic 140-159, diastolic 90-99 Stage 2 - Systolic equal to or more than 160, diastolic equal to or more than 100.