Nazma Akter Tithi

Chemical and Biological Investigations of Typhonium trilobatum Nazma Akter Tithi

Typhonium trilobatum (L.) Schott of the family Aracae has been considered as an important plant in traditional medicine practices in Bangladesh. As very few scientific investigations were performed on this plant, the aim of the present study was to evaluate the phytochemical constituents and pharmacological activities of Typhonium trilobatum. In this study, phytochemical screening, in-vitro antioxidant activity, in-vitro thrombolytic and membrane stabilizing activities, in-vivo anti-spasmodic activity, in-vivo anti-depressant activity and acute toxicity were investigated. Standard qualitative chemical tests were performed as phytochemical screening and the presence of flavonoids, phenols, and alkaloids was detected in various parts of the plant. Six different assays were performed to evaluate antioxidant activity and the leaf extracts showed good potential. The plant showed significant thrombolytic effect, human RBC membrane stabilizing effect, GI motility and potent dose dependent anti-depressant effect.